Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins
Y Chen, R Wan, Z Zou, L Lao, G Shao, Y Zheng… - Nature Cell …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …
modification in mammals, regulating critical aspects of cell physiology and differentiation …
A little sugar goes a long way: the cell biology of O-GlcNAc
MR Bond, JA Hanover - Journal of Cell Biology, 2015 - rupress.org
Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …
Interpreting the language of histone and DNA modifications
SB Rothbart, BD Strahl - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …
covalent modifications to DNA and histone proteins that dependably package our genetic …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
Hyaluronidases: their genomics, structures, and mechanisms of action
R Stern, MJ Jedrzejas - Chemical reviews, 2006 - ACS Publications
The hyaluronidases (Hyals) are classes of enzymes that degrade, predominantly,
hyaluronan (HA). The term “hyaluronidase” is somewhat of a misnomer since they have the …
hyaluronan (HA). The term “hyaluronidase” is somewhat of a misnomer since they have the …
linking metabolism to epigenetics through O-GlcNAcylation
JA Hanover, MW Krause, DC Love - Nature reviews Molecular cell …, 2012 - nature.com
O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …
Demystifying the O-GlcNAc code: a systems view
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
O-linked β-N-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress
C Butkinaree, K Park, GW Hart - … et Biophysica Acta (BBA)-General Subjects, 2010 - Elsevier
BACKGROUND: Since its discovery in the early 1980s, O-linked-β-N-acetylglucosamine (O-
GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues …
GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues …