Cancer led to the deaths of more than 9 million people worldwide in 2018, and most of these
deaths were due to metastatic tumor burden. While in most cases, we still do not know why …

Background Aberrant DNA replication is the main source of genomic instability that leads to
tumorigenesis and progression. MCM2, a core subunit of eukaryotic helicase, plays a vital …

Background Chemotherapy and gene therapy are used in clinical practice for the treatment
of castration-resistant prostate cancer. However, the poor efficiency of drug delivery and …

Objectives We aimed to construct an induction system for polyploid giant cancer cells
(PGCCs), as well as to investigate PGCC features and clinical significance. Methods A …

Nucleostemin (NS; a product of the GNL3 gene) is a nucleolar–nucleoplasm shuttling
GTPase whose levels are high in stem cells and rapidly decrease upon differentiation. NS …

Nucleostemin (NS) is a vertebrate gene preferentially expressed in stem and cancer cells,
which acts to regulate cell cycle progression, genome stability and ribosome biogenesis. NS …

The nucleolus is a subnuclear compartment with key roles in rRNA synthesis and ribosome
biogenesis, complex processes that require hundreds of proteins and factors. Alterations in …

IMP dehydrogenase (IMPDH) inhibition has emerged as a new target therapy for
glioblastoma multiforme (GBM), which remains one of the most refractory tumors to date …

Nucleostemin (NS) plays a role in liver regeneration, and aging reduces its expression in the
baseline and regenerating livers following 70% partial hepatectomy (PHx). Here we …

Stem cells are endowed with the awesome power of self-renewal and multi-lineage
differentiation that allows them to be major contributors to tissue homeostasis. Owing to their …