Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although
matrix‐embedded osteocytes are considered as the key mechanoresponsive bone cells, all …

Sulfation is a widespread modification of biomolecules that has been incompletely explored
to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 …

Nearly all structures in our body experience mechanical forces. At a molecular scale, these
forces are detected by ion channels that function as mechanotransducers converting …

PIEZO1 and PIEZO2 are mechanosensitive cation channels that are highly expressed in
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of
representative reference panels, thus hindering the discovery of ancestry-specific variants …

Objectives and methods With 432 513 samples from UK Biobank dataset, multivariable
linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic …

Background Birth weight is considered not only to undermine future growth, but also to
induce lifelong diseases; the aim of this study is to explore the relationship between birth …