Leishmania, the causative agent of leishmaniases, is an intracellular parasite of
macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan …

This mini-review focuses on leishmanicidal drugs that were sourced from small molecules
previously approved for other diseases. The mechanisms of action of these molecules are …

Cholesterol is an essential component of higher eukaryotic membranes and plays a crucial
role in membrane organization, dynamics and function. The G-protein coupled receptors …

G-protein coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across membranes, and represent major targets in the development of novel …

Statins are potent inhibitors of HMG-CoA reductase, the key rate-limiting enzyme in
cholesterol biosynthesis, and are some of the best selling drugs globally. We have explored …

Visceral leishmaniasis (VL) is caused by various species of the genus Leishmania.
Internalization of Leishmania into host cells is facilitated by a large number of receptors, and …

Introduction: Among the drugs in clinical use for the treatment of leishmaniases,
amphotericin B (AmB) is the most effective and has been the most extensively studied for the …

Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

The current paradigm for managing infectious diseases has targeted unique processes or
enzymes within pathogens. A serious disadvantage of this pathogen-directed drug targeting …