Multiple sclerosis: immunopathology and treatment update
N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
Microbiome in multiple sclerosis: Where are we, what we know and do not know
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …
and this may be connected to environmental factors. This review article aims to encapsulate …
Myelin basic protein—diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis
G Harauz, N Ishiyama, CMD Hill, IR Bates, DS Libich… - Micron, 2004 - Elsevier
The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
Review cyclic peptides on a merry‐go‐round; towards drug design
A Tapeinou, MT Matsoukas, C Simal… - Peptide Science, 2015 - Wiley Online Library
Peptides and proteins are attractive initial leads for the rational design of bioactive
molecules. Several natural cyclic peptides have recently emerged as templates for drug …
molecules. Several natural cyclic peptides have recently emerged as templates for drug …
[HTML][HTML] Matrix metalloproteinases–From the cleavage data to the prediction tools and beyond
P Cieplak, AY Strongin - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …
cleavage substrates and their relative cleavage efficacy as compared with other substrates …
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis
Background Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of
myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis …
myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis …
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
Celiac disease is an immune mediated enteropathy elicited by gluten ingestion. The
disorder has a strong association with HLA-DQ2. This HLA molecule is involved in the …
disorder has a strong association with HLA-DQ2. This HLA molecule is involved in the …
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
H Liu, SA Shiryaev, AV Chernov, Y Kim… - Journal of …, 2012 - Springer
Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent
fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The …
fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The …
Development and characterization of a novel conjugated methamphetamine vaccine
Background Methamphetamine (METH) addiction is a major public health concern globally
with limited management options. The development of a METH vaccine through hapten …
with limited management options. The development of a METH vaccine through hapten …
Antigen-specific treatment modalities in MS: The past, the present, and the future
J Derdelinckx, P Cras, ZN Berneman… - Frontiers in …, 2021 - frontiersin.org
Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by
induction of tolerance to a wide range of myelin-derived antigens without hampering the …
induction of tolerance to a wide range of myelin-derived antigens without hampering the …