Perturbation of mitochondrial function can trigger a host of cellular responses that seek to
restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases …

Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

The role of cytosolic stress granules in the integrated stress response has remained largely
enigmatic. Here, we studied the functionality of the ubiquitin‐proteasome system (UPS) in …

The heat shock response (HSR) controls expression of molecular chaperones to maintain
protein homeostasis. Previously, we proposed a feedback loop model of the HSR in which …

The Hsp70 chaperone system is a central component of cellular protein quality control
(PQC) by acting in a multitude of protein folding processes ranging from the folding of newly …

Organismal proteostasis is maintained by intercellular signaling processes including cell
nonautonomous stress responses such as transcellular chaperone signaling (TCS). When …

A key factor in the successful infection of a mammalian host by Leishmania parasites is their
conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss …

Cardiovascular diseases (CVDs) are the leading cause of death globally, representing
approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart …

The differentiation of neural progenitors is a complex process that integrates different signals
to drive transcriptional changes, which mediate metabolic, electrophysiological, and …

Climate change is increasingly affecting the quality of life of organisms on Earth. More
frequent, extreme, and lengthy heat waves are contributing to the sixth mass extinction of …