The envelope (E) protein of SARS-coV-2 as a pharmacological target

T Santos-Mendoza - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern.
Several spike (S) protein-based vaccines have been developed that efficiently protect the …

Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes

V Bondarenko, Q Chen, TS Tillman, Y Xu… - ACS chemical …, 2024 - ACS Publications
PDZ domains are modular domains that conventionally bind to C terminal or internal motifs
of target proteins to control cellular functions through the regulation of protein complex …

Modeling of host PDZ-dependent interactions with SARS-CoV-2 Envelope protein and changes in PDZ proteins expression in macrophages and dendritic cells

J Rosas-García, AJ Padilla-Zúñiga… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins constitute a large family of
scaffolds involved in a wide range of cellular tasks, and mainly studied in polarity functions …

A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

V Young, B Dohai, TCA Hitch, P Hyden, B Weller… - bioRxiv, 2023 - biorxiv.org
The molecular mechanisms by which the gut microbiome influences human health remain
largely unknown. Pseudomonadota is the third most abundant phylum in normal gut …

Protein Networks in Human Disease

KM Poluri, K Gulati, DK Tripathi, N Nagar - Protein-Protein Interactions …, 2023 - Springer
Anomalies in protein–protein interactions may lead to a diseased state, as many cellular
functions are sustained by such interactions. These abnormal situations usually arise when …

[PDF][PDF] Análisis de la expresión y función de proteínas PDZ en células presentadoras de antígeno profesionales humanas

J Rosas García - 2023 - repositorio.cinvestav.mx
El estudio de las proteínas se ha estado enfocado a analizar polipéptidos estables y
plegados con estructuras bien definidas. Una característica recurrente de tales polipéptidos …

[PDF][PDF] Molecular mechanisms and specialized roles of Dishevelled paralogs

J Kumar - is.muni.cz
Wnt signaling is a critical and evolutionarily conserved pathway involved in a wide range of
biological processes, such as cell development, differentiation, and tissue homeostasis …

[图书][B] Exploring the Role of Localized mRNAs and RNA Binding Proteins In the Regulation of Epithelial Cell Polarity

A Chin - 2022 - search.proquest.com
Epithelial cells are asymmetrically organized, and their polarization is reliant on the
presence of cell junctions. However, this organization is frequently altered in carcinomas …