Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

L Galluzzi, JM Bravo-San Pedro, B Levine… - Nature reviews Drug …, 2017 - nature.com
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

Hydrocephalus after subarachnoid hemorrhage: pathophysiology, diagnosis, and treatment

S Chen, J Luo, C Reis, A Manaenko… - BioMed research …, 2017 - Wiley Online Library
Hydrocephalus (HCP) is a common complication in patients with subarachnoid hemorrhage.
In this review, we summarize the advanced research on HCP and discuss the understanding …

Autophagy in acute brain injury

L Galluzzi, JM Bravo-San Pedro, K Blomgren… - Nature Reviews …, 2016 - nature.com
Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …

Astaxanthin as a potential neuroprotective agent for neurological diseases

H Wu, H Niu, A Shao, C Wu, BJ Dixon, J Zhang, S Yang… - Marine drugs, 2015 - mdpi.com
Neurological diseases, which consist of acute injuries and chronic neurodegeneration, are
the leading causes of human death and disability. However, the pathophysiology of these …

Acyl‐CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis

X Qu, T Liang, D Wu, N Lai, R Deng… - CNS neuroscience & …, 2021 - Wiley Online Library
Abstract Aims Acyl‐CoA synthetase long chain family member 4 (ACSL4) is closely related
to tumor genesis and development in certain tissues. However, the function of ACSL4 in …

Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-κB …

A Shao, H Wu, Y Hong, S Tu, X Sun, Q Wu… - Molecular …, 2016 - Springer
Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h
after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent …

[HTML][HTML] 3, 4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

H Zhang, W Ni, G Yu, Y Geng, J Lou, J Qi, Y Chen… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric
restriction (CR) and have been shown to have therapeutic effects in neuroinflammatory …

A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB

Y Lin, Q Shi, G Yang, F Shi, Y Zhou… - Proceedings of the …, 2023 - National Acad Sciences
Autophagy supports the fast growth of established tumors and promotes tumor resistance to
multiple treatments. Inhibition of autophagy is a promising strategy for tumor therapy …

Xanthophyll: Health benefits and therapeutic insights

E Aziz, R Batool, W Akhtar, S Rehman, T Shahzad… - Life sciences, 2020 - Elsevier
Xanthophylls constitute a major part of carotenoids in nature. They are an oxidized version
of carotenoid. Xanthophyll has widely drawn scientists' attentions in terms of its functionality …

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation

C Fu, X Zhang, Y Lu, F Wang, Z Xu, S Liu… - International …, 2020 - Elsevier
The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral
ischemia. Autophagy may cause microglial inflammatory response or stimulate microglial …