Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

S Song, Z Xiao, FJ Dekker, GJ Poelarends… - Cellular and Molecular …, 2022 - Springer
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

M Chaffin, I Papangeli, B Simonson, AD Akkad, MC Hill… - Nature, 2022 - nature.com
Heart failure encompasses a heterogeneous set of clinical features that converge on
impaired cardiac contractile function, and presents a growing public health concern …

Hallmarks of cancer affected by the MIF cytokine family

R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …

MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model

PV Tilstam, W Schulte, T Holowka… - The Journal of …, 2021 - Am Soc Clin Investig
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …

The role of CD74 in cardiovascular disease

QL Li, J Tang, L Zhao, A Ruze, XF Shan… - Frontiers in …, 2023 - frontiersin.org
Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular
chaperone of major histocompatibility complex class II (MHC II) molecules involved in …

D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF?

C Zan, B Yang, M Brandhofer… - Faseb …, 2022 - epub.ub.uni-muenchen.de
Macrophage migration inhibitory factor (MIF) as well as its more recently described structural
homolog D-dopachrome tautomerase (D-DT), now also termed MIF-2, are atypical cytokines …

Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny

Y Li, JP Johnson, Y Yang, D Yu… - American Journal …, 2023 - journals.physiology.org
Maternal hypothyroidism (MH) could adversely affect the cardiac disease responses of the
progeny. This study tested the hypothesis that MH reduces early postnatal cardiomyocyte …

CmyoSize: An ImageJ macro for automated analysis of cardiomyocyte size in images of routine histology staining

FS da Silva, NCSA de Souza, MV de Moraes… - Annals of Anatomy …, 2022 - Elsevier
Background Cardiomyocyte size histomorphometry is widely required in myocardial
remodeling research, but it relies on subjective, time-consuming manual tracing. We aimed …

Immune modulation by the macrophage migration inhibitory factor (MIF) family: D-dopachrome tautomerase (DDT) is not (always) a backup system

O Illescas, T Pacheco-Fernández, JP Laclette… - Cytokine, 2020 - Elsevier
Human macrophage migration inhibition factor (MIF) is a protein with cytokine and
chemokine properties that regulates a diverse range of physiological functions related to …

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

OE Bounkari, C Zan, J Wagner, E Bugar, P Bourilhon… - bioRxiv, 2021 - biorxiv.org
Atherosclerosis is the underlying cause of cardiovascular diseases (CVDs) such as
myocardial infarction and ischemic stroke. It is a lipid-triggered chronic inflammatory …