ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …

Stress granules (SGs) are nonmembrane assemblies formed in cells in response to stress
conditions. SGs mainly contain untranslated mRNA and a variety of proteins. RNAs and …

The elimination of aberrant inclusions is regarded as a therapeutic approach in
neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found …

Ubiquitination is a reversible post-translational modification based on the chemical addition
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …

Adenosine diphosphate (ADP)-ribosylation is a posttranslational modification involved in
key regulatory events catalyzed by ADP-ribosyltransferases (ARTs). Substrate identification …

Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …

The innate immune system, the primary defense mechanism of higher organisms against
pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In …

Mono (ADP-ribose) transferases and mono (ADP-ribosyl) ating sirtuins use NAD+ to perform
the mono (ADP-ribosyl) ation, a simple form of post-translational modification of proteins …