Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

DG Yu, W Gong, J Zhou, Y Liu, Y Zhu… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
The shapes of micro‐and nano‐products have profound influences on their functional
performances, which has not received sufficient attention during the past several decades …

Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane

JW Choi, J Youn, DS Kim, TE Park - Biomaterials, 2023 - Elsevier
The basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix
(ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial …

Intersection of nanomaterials and organoids technology in biomedicine

C Shen, Z Zhang, X Li, Y Huang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the
conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types …

Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen‐Permeable Microwell Device for Anti‐Tumor Drug Evaluation

J He, C Zhou, X Xu, Z Zhou, M Danoy… - Advanced …, 2022 - Wiley Online Library
For high‐throughput anti‐cancer drug screening, microwell arrays may serve as an effective
tool to generate uniform and scalable tumor spheroids. However, microwell arrays are …

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

D Kim, J Youn, J Lee, H Kim… - Macromolecular …, 2023 - Wiley Online Library
Nanofiber membranes (NFMs), which have an extracellular matrix‐mimicking structure and
unique physical properties, have garnered great attention as biomimetic materials for …

[HTML][HTML] Facile and adhesive-free method for bonding nanofiber membrane onto thermoplastic polystyrene substrate to fabricate 3D cell culture platforms

J Youn, J Rhyou, D Kim, J Lee, JW Choi, TE Park… - Materials Today Bio, 2023 - Elsevier
Nanofiber (NF) membranes have been highlighted as functional materials for biomedical
applications owing to their high surface-to-volume ratios, high permeabilities, and …

A Perforated Plate-Based Cell Showering Device for Uniform Cell Distribution over Various Culture Substrates

F Mustafayev, J Youn, A Hanif… - ACS Biomaterials Science …, 2023 - ACS Publications
Cell distribution is one of the primary factors that can affect cell morphology and behaviors,
as it determines cell–cell interactions. Despite the importance of cell distribution, the seeding …

Enhanced differentiation capacity and transplantation efficacy of insulin-producing cell clusters from human iPSCs using permeable nanofibrous microwell-arrayed …

IK Shim, SJ Lee, YN Lee, D Kim, H Goh, J Youn, J Jang… - Pharmaceutics, 2022 - mdpi.com
Although pancreatic islet transplantation is a potentially curative treatment for insulin-
dependent diabetes, a shortage of donor sources, low differentiation capacity, and …

[PDF][PDF] Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane

DS Kim, D Kim, H Lim, J Youn, TE Park - 2023 - scholar.archive.org
The application of organoids has been limited by the lack of methods for producing uniformly
mature organoids at scale. This study introduces an organoid culture platform, called …