Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

The hypothalamic-pituitary adrenal axis is a complex system of neuroendocrine pathways
and feedback loops that function to maintain physiological homeostasis. Abnormal …

Background Diagnosing polycystic ovary syndrome (PCOS) during adolescence is
challenging because features of normal pubertal development overlap with adult diagnostic …

Objective: This clinical practice guideline addresses the diagnosis and treatment of primary
adrenal insufficiency. Participants: The Task Force included a chair, selected by The Clinical …

The term differences of sex development (DSDs; also known as disorders of sex
development) refers to a heterogeneous group of congenital conditions affecting human sex …

Objective: The aim was to formulate practice guidelines for the diagnosis and treatment of
polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task …

Abstract Objective To update the “Evaluation and Treatment of Hirsutism in Premenopausal
Women: An Endocrine Society Clinical Practice Guideline,” published by the Endocrine …

ABSTRACT The Standards of Care (SOC) for the Health of Transsexual, Transgender, and
Gender Nonconforming People is a publication of the World Professional Association for …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …