Background Several associations between microsatellite instability (MSI) and other
clinicopathological factors have been reported in gastric cancer, but the results have been …

More than 1.6 million new cases of cancer will be diagnosed in the US in 2016, resulting in
more than 500,000 deaths. Although chemotherapy has been the mainstay of treatment in …

Microsatellite instability determines whether patients with gastrointestinal cancer respond
exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested …

China is one of the countries with the highest incidence of gastric cancer. There are
differences in epidemiological characteristics, clinicopathological features, tumor biological …

Chemotherapy and targeted therapy are the major treatments for gastric cancer (GC), but
drug resistance limits its effectiveness. Here, we profile the proteome of 206 tumor tissues …

Purpose Microsatellites are widely distributed repetitive DNA motifs, accounting for
approximately 3% of the genome. Due to mismatch repair system deficiency, insertion or …

Despite a decrease in gastric cancer incidence, the development of novel biologic agents
and combined therapeutic strategies, the prognosis of gastric cancer remains poor …

Gastric cancer is the fifth most incident and the third most common cause of cancer-related
death in the world. Infection with Helicobacter pylori is the major risk factor for this disease …

Purpose: This randomized, multicenter, open-label, phase Ib/II study assessed durvalumab
and tremelimumab in combination or as monotherapy for chemotherapy-refractory gastric …

Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due
to expanded DNA (TA) n dinucleotide repeats. WRN is a promising synthetic lethal target for …