D Yang, JL Leibowitz - Virus research, 2015 - Elsevier
Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most human coronaviruses commonly cause relatively mild respiratory illnesses; however two …
GJ Park, A Osinski, G Hernandez, JL Eitson… - Nature, 2022 - nature.com
The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases and evasion of the host immune response,,–. How …
Summary mRNA modifications play important roles in regulating gene expression. One of the most abundant mRNA modifications is N6, 2-O-dimethyladenosine (m6Am). Here, we …
JM Kyriakis, J Avruch - Physiological reviews, 2012 - journals.physiology.org
The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in …
The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …
K Inoki, Y Li, T Zhu, J Wu, KL Guan - Nature cell biology, 2002 - nature.com
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 …
JM Kyriakis, J Avruch - Physiological reviews, 2001 - journals.physiology.org
The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite the fact that the impact of these pathways on the …
K Hara, Y Maruki, X Long, K Yoshino, N Oshiro… - Cell, 2002 - cell.com
Abstract mTOR controls cell growth, in part by regulating p70 S6 kinase α (p70α) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding …
All eukaryotic cells have an extensive membranous labyrinth network of branching tubules and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all …