DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

The oral cavity and oropharynx are complex environments that are susceptible to physical,
chemical, and microbiological insults. They are also common sites for pathological and …

Guided bone regeneration (GBR) has become a clinically standard modality for the
treatment of localized jawbone defects. Barrier membranes play an important role in this …

Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …

Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Bone is a hard-connective tissue composed of matrix, cells and bioactive factors with a
hierarchical structure, where the matrix is mainly composed of type I collagen and …

Large bone defects are usually managed by replacing lost bone with non-biological
prostheses or with bone grafts that come from the patient or a donor. Bone tissue …

Intraoperative bioprinting (IOB), which refers to the bioprinting process performed on a live
subject in a surgical setting, has made it feasible to directly deliver gene-activated matrices …

Initiation of endogenous repair mechanisms, including key steps of stem cell recruitment and
cartilage intermediate formation in endochondral ossification, is vital to regeneration of large …