The p53 protein is a transcription factor that prevents tumors from developing. In
spontaneous and inherited cancers there are many different missense mutations in the DNA …

Genome compaction is a universal feature of cells and has emerged as a global regulator of
gene expression. Compaction is maintained by a multitude of architectural proteins, long …

AKT kinase is a key regulator in cell metabolism and survival, and its activation is strictly
modulated. Herein, we identify XAF1 (XIAP-associated factor) as a direct interacting protein …

Cancer risk is highly variable in carriers of the common TP53-R337H founder allele,
possibly due to the influence of modifier genes. Whole-genome sequencing identified a …

CTCF, Zinc-finger protein, has been identified as a multifunctional transcription factor that
regulates gene expression through various mechanisms, including recruitment of other co …

Simple Summary Lung cancer is one of the most commonly diagnosed cancers worldwide
and the most common cause of cancer-related deaths. During lung carcinogenesis …

The association between obesity and breast cancer risk and prognosis is well established in
estrogen receptor (ER)-positive disease but less clear in HER2-positive disease. Here, we …

Protocadherins (PCDHs) are a group of transmembrane proteins belonging to the cadherin
superfamily and are subdivided into “clustered” and “non-clustered” groups. PCDHs vary in …

XAF1 is a tumor suppressor gene with low or absent expression in cancer. Since
transcriptional reactivation or ectopic-mediated expression of XAF1 inhibits tumor growth, it …

Aptamers are short, single-stranded DNA or RNA oligonucleotides that bind with high
specificity and affinity to a target molecule due to their unique, sequence-dependent …