A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Exosome treatment enhances anti-inflammatory M2 macrophages and reduces inflammation-induced pyroptosis in doxorubicin-induced cardiomyopathy

DK Singla, TA Johnson, Z Tavakoli Dargani - Cells, 2019 - mdpi.com
Doxorubicin (Dox) is an effective antineoplastic agent used to treat cancers, but its use is
limited as Dox induces adverse cardiotoxic effects. Dox-induced cardiotoxicity (DIC) can …

Present and future of bronchopulmonary dysplasia

L Bonadies, P Zaramella, A Porzionato… - Journal of clinical …, 2020 - mdpi.com
Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder among infants
born extremely preterm. The pathogenesis of BPD involves multiple prenatal and postnatal …

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

[HTML][HTML] Mesenchymal stromal cells and exosomes: progress and challenges

MH Forsberg, JA Kink, P Hematti… - Frontiers in cell and …, 2020 - frontiersin.org
Due to their robust immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs)
have been used as a cellular therapy for a number of human diseases. Part of the …

Extracellular vesicles protect the neonatal lung from hyperoxic injury through the epigenetic and transcriptomic reprogramming of myeloid cells

GR Willis, M Reis, AH Gheinani… - American Journal of …, 2021 - atsjournals.org
Rationale: Mesenchymal stem/stromal cell (MSC)–small extracellular vesicle (MEx)
treatment has shown promise in experimental models of neonatal lung injury. The molecular …

Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis

A Tieu, K Hu, C Gnyra, J Montroy… - Journal of …, 2021 - Wiley Online Library
Preclinical studies suggest mesenchymal stromal cell extracellular vesicles (MSC‐EVs)
reduce inflammation and improve organ function in lung diseases; however, an objective …

[HTML][HTML] Exosomes as drug delivery systems: endogenous nanovehicles for treatment of systemic lupus erythematosus

A Ortega, O Martinez-Arroyo, MJ Forner, R Cortes - Pharmaceutics, 2021 - mdpi.com
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have
attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes …

Stem-cell therapy for bronchopulmonary dysplasia (BPD) in newborns

SA Omar, A Abdul-Hafez, S Ibrahim, N Pillai… - Cells, 2022 - mdpi.com
Premature newborns are at a higher risk for the development of respiratory distress
syndrome (RDS), acute lung injury (ALI) associated with lung inflammation, disruption of …