ABSTRACT RNA-binding proteins are a critical group of multifunctional proteins that
precisely regulate all aspects of gene expression, from alternative splicing to mRNA …

Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months to years for reaching …

Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …

The role of alternative splicing is one of the great unanswered questions in cellular biology.
There is strong evidence for alternative splicing at the transcript level, and transcriptomics …

Cardiomyocytes undergo significant structural and functional changes after birth, and these
fundamental processes are essential for the heart to pump blood to the growing body …

Common variation in the gene encoding the neuron-specific RNA splicing factor RNA
Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk factor for several …

The enormous cellular diversity in the mammalian brain, which is highly prototypical and
organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory …

Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose
homeostasis. Although the molecular components of insulin granule trafficking and secretion …

Proper assembly and function of the nervous system requires the generation of a uniquely
diverse population of neurons expressing a cell-type-specific combination of effector genes …