The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Biomolecular phase separation: from molecular driving forces to macroscopic properties
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …
recently been extended to a new class of biomolecules that form liquid-like droplets …
A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain
TAR DNA-binding protein 43 (TDP-43) is involved in key processes in RNA metabolism and
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Neuronal inclusions of aggregated RNA‐binding protein fused in sarcoma (FUS) are
hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly …
hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly …
ALS mutations disrupt phase separation mediated by α-helical structure in the TDP-43 low-complexity C-terminal domain
RNA-binding protein TDP-43 mediates essential RNA processing but forms cytoplasmic
neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It …
neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It …
Relation between single-molecule properties and phase behavior of intrinsically disordered proteins
Proteins that undergo liquid–liquid phase separation (LLPS) have been shown to play a
critical role in many physiological functions through formation of condensed liquid-like …
critical role in many physiological functions through formation of condensed liquid-like …
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads
The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in
biomolecular condensates and functions in transcription by clustering with RNA polymerase …
biomolecular condensates and functions in transcription by clustering with RNA polymerase …
[HTML][HTML] CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
AS Holehouse, RK Das, JN Ahad, MOG Richardson… - Biophysical journal, 2017 - cell.com
Intrinsically disordered proteins and regions (IDPs) represent a large class of proteins that
are defined by conformational heterogeneity and lack of persistent tertiary/secondary …
are defined by conformational heterogeneity and lack of persistent tertiary/secondary …
Temperature-controlled liquid–liquid phase separation of disordered proteins
The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is a
commonly observed phenomenon within the cell, and such condensates are also highly …
commonly observed phenomenon within the cell, and such condensates are also highly …
Phase separation in biology; functional organization of a higher order
DM Mitrea, RW Kriwacki - Cell Communication and Signaling, 2016 - Springer
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …
compartments and, within these, some are further organized into non-membrane-bounded …