[HTML][HTML] Recent developments in adenosine receptor ligands and their potential as novel drugs
CE Müller, KA Jacobson - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …
The A3 adenosine receptor: history and perspectives
By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …
regulator of local tissue function, especially when energy supply fails to meet cellular energy …
Selectivity is species-dependent: characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors
MW Alnouri, S Jepards, A Casari, AC Schiedel… - Purinergic …, 2015 - Springer
Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on
affinity/potency and selectivity of AR ligands described in the literature has been obtained for …
affinity/potency and selectivity of AR ligands described in the literature has been obtained for …
G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions
KA Jacobson, R Balasubramanian, F Deflorian… - Purinergic …, 2012 - Springer
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …
Adenosine, adenosine receptors and glaucoma: an updated overview
Y Zhong, Z Yang, WC Huang, X Luo - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
BACKGROUND: Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …
Species dependence of A3 adenosine receptor pharmacology and function
ZG Gao, JA Auchampach, KA Jacobson - Purinergic Signalling, 2023 - Springer
Efforts to fully understand pharmacological differences between G protein-coupled receptor
(GPCR) species homologues are generally not pursued in detail during the drug …
(GPCR) species homologues are generally not pursued in detail during the drug …
Adenosine receptor targeting in health and disease
Introduction: The adenosine receptors A1, A2A, A2B and A3 are important and ubiquitous
mediators of cellular signaling that play vital roles in protecting tissues and organs from …
mediators of cellular signaling that play vital roles in protecting tissues and organs from …
Adenosine receptors in health and disease
The adenosine receptors A 1, A 2A, A 2B, and A 3 are important and ubiquitous mediators of
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …
Discovery of molecular therapeutics for glaucoma: challenges, successes, and promising directions: miniperspective
RK Donegan, RL Lieberman - Journal of medicinal chemistry, 2016 - ACS Publications
Glaucoma, a heterogeneous ocular disorder affecting∼ 60 million people worldwide, is
characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in …
characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in …
Pharmacological management of ocular hypertension: current approaches and future prospective
Elevated eye pressure is the main risk factor for glaucoma, and intraocular pressure rises
when the balance between aqueous humor formation and outflow resistance is …
when the balance between aqueous humor formation and outflow resistance is …