Through various pathways of cell death, degradation, and regulated extrusion, partial or
complete genomes of various origins (eg, host cells, fetal cells, and infiltrating viruses and …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Simple Summary Breast cancer is the most common cancer and leading cause of death
worldwide. Therefore, it is important to diagnose and treat breast cancer early. Current …

All cell and tissue types constantly release DNA fragments into human body fluids by various
mechanisms including programmed cell death, accidental cell degradation and active …

Fragments of cell-free DNA (cfDNA) in human body fluids often carry disease-specific
alterations and are now widely recognized as ideal biomarkers for the detection and …

Recent advances in basic research have unveiled several strategies for improving the
sensitivity and specificity of cell-free DNA (cfDNA) based assays, which is a prerequisite for …

Simple Summary Autotaxin (ATX) has been linked with the pathogenesis of several cancers
and especially with breast cancer (BC). BC is one of the most common cancers among …

Simple Summary Breast cancer (BrCa) is characterized by aberrant DNA methylation. We
leveraged high-throughput methylation data from BrCa and normal breast tissues and …

Early diagnosis of cancer improves the efficacy of curative therapies. However, due to the
difficulties involved in distinguishing between small early-stage tumors and normal …

In vitro characterization of cell-free DNA using two-dimensional cell culture models is
emerging as an important step toward an improved understanding of the physical and …