Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …

Development of improved approaches for HIV-1 prevention will likely be required for a
durable end to the global AIDS pandemic. Recent advances in preclinical studies and early …

BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …

Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …

Combination antiretroviral therapy (ART) is highly effective in controlling human
immunodeficiency virus (HIV)-1 but requires lifelong medication due to the existence of a …

Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir | Journal of
Experimental Medicine | Rockefeller University Press Skip to Main Content Advertisement …

HIV-1 infection requires lifelong therapy with antiretroviral drugs due to the existence of a
latent reservoir of transcriptionally inactive integrated proviruses. The goal of HIV-1 cure …

Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4+ T cells that can
undergo clonal expansion in vivo. Expanded clones of CD4+ T cells dominate latent …

HIV-1 persists as a latent reservoir in people receiving suppressive antiretroviral therapy
(ART). When ART is interrupted (treatment interruption/TI), rebound virus re-initiates …

Clonal expansion of HIV-infected cells contributes to the long-term persistence of the HIV
reservoir in ART-suppressed individuals. However, the contribution from cell clones that …