The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

MKRN3 mutations represent the most common genetic cause of central precocious puberty
(CPP) but associations between genotype and clinical features have not been extensively …

Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Puberty involves a series of morphological, physiological and behavioural changes during
the last part of the juvenile period that culminates in the attainment of fertility. The activation …

Background: Mutations in the imprinted gene MKRN3 have been described as a common
genetic cause of idiopathic central precocious puberty (CPP), in particular in familial cases …

Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …

Central precocious puberty (CPP) is a condition in which the hypothalamus–pituitary–
gonadal system is activated earlier than the normal developmental stage. The etiology …

Background Central precocious puberty (CPP) due to premature activation of GnRH
secretion results in early epiphyseal fusion and to a significant compromise in the achieved …

Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic–pituitary–
gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central …