The ubiquitin system

A Hershko, A Ciechanover - Annual review of biochemistry, 1998 - annualreviews.org
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

The Ubiquitin–Proteasome System of Saccharomyces cerevisiae

D Finley, HD Ulrich, T Sommer, P Kaiser - Genetics, 2012 - academic.oup.com
Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

COI1: An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility

DX Xie, BF Feys, S James, M Nieto-Rostro, JG Turner - Science, 1998 - science.org
The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which
regulate defense against insects and pathogens, wound healing, and pollen fertility. The …

[HTML][HTML] SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

C Bai, P Sen, K Hofmann, L Ma, M Goebl, JW Harper… - Cell, 1996 - cell.com
We have identified the yeast and human homologs of the SKP1 gene as a suppressor of
cdc4 mutants and as a cyclin F–binding protein. Skp1p indirectly binds cyclin A/Cdk2 …

The yeast cell-cycle network is robustly designed

F Li, T Long, Y Lu, Q Ouyang… - Proceedings of the …, 2004 - National Acad Sciences
The interactions between proteins, DNA, and RNA in living cells constitute molecular
networks that govern various cellular functions. To investigate the global dynamical …

[HTML][HTML] F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

D Skowyra, KL Craig, M Tyers, SJ Elledge, JW Harper - Cell, 1997 - cell.com
We have reconstituted the ubiquitination pathway for the Cdk inhibitor Sic1 using
recombinant proteins. Skp1, Cdc53, and the F-box protein Cdc4 form a complex, SCF Cdc4 …

Metabolism of sulfur amino acids in Saccharomyces cerevisiae

D Thomas, Y Surdin-Kerjan - Microbiology and Molecular Biology …, 1997 - Am Soc Microbiol
Sulfur amino acid biosynthesis in Saccharomyces cerevisiae involves a large number of
enzymes required for the de novo biosynthesis of methionine and cysteine and the recycling …

SCF and Cullin/Ring H2-based ubiquitin ligases

RJ Deshaies - Annual review of cell and developmental biology, 1999 - annualreviews.org
▪ Abstract Protein degradation is deployed to modulate the steady-state abundance of
proteins and to switch cellular regulatory circuits from one state to another by abrupt …

The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana

T Straub, U Ludewig, B Neuhäuser - The Plant Cell, 2017 - academic.oup.com
Ion transport in plants is not only strictly regulated on a transcriptional level, but it is also
regulated posttranslationally. Enzyme modifications such as phosphorylation provide rapid …

Function and regulation of yeast hexose transporters

S Özcan, M Johnston - Microbiology and Molecular Biology …, 1999 - Am Soc Microbiol
Glucose, the most abundant monosaccharide in nature, is the principal carbon and energy
source for nearly all cells. The first, and rate-limiting, step of glucose metabolism is its …