Epidermolysis bullosa (EB) is an inherited, heterogeneous group of rare genetic dermatoses
characterized by mucocutaneous fragility and blister formation, inducible by often minimal …

Background Several new genes and clinical subtypes have been identified since the
publication in 2014 of the report of the last International Consensus Meeting on …

The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

Phenotypic drug discovery (PDD) approaches do not rely on knowledge of the identity of a
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …

Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds
with multifactorial etiologies that are associated with high patient morbidity and mortality …

Epidermolysis bullosa (EB) is a heterogeneous group of inherited skin disorders determined
by mutations in genes encoding for structural components of the cutaneous basement …

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin fragility disorder
caused by loss-of-function mutations in the COL7A1 gene, which encodes type VII collagen …

Wound healing is one of the most complex processes in multicellular organisms, involving
numerous intra-and intercellular signalling pathways in various cell types. It involves …

An extracellular matrix (ECM) is a prerequisite for multicellular life. It is adapted to tissues
and constantly undergoes changes to preserve microenvironmental homeostasis. The ECM …

Dystrophic epidermolysis bullosa (DEB) is one of the major types of EB, a rare hereditary
group of trauma-induced blistering skin disorders. DEB is caused by inherited pathogenic …