Genetic architecture of childhood speech disorder: a review
AT Morgan, DJ Amor, MD St John, IE Scheffer… - Molecular …, 2024 - nature.com
Severe speech disorders lead to poor literacy, reduced academic attainment and negative
psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was …
psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was …
Targeting WD repeat-containing protein 5 (WDR5): a medicinal chemistry perspective
X Chen, J Xu, X Wang, G Long, Q You… - Journal of medicinal …, 2021 - ACS Publications
WD repeat-containing protein 5 (WDR5) is a member of the WD40 protein family, and it is
widely involved in various biological activities and not limited to epigenetic regulation in …
widely involved in various biological activities and not limited to epigenetic regulation in …
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics
Pancreatic cancer (PC), one of the most aggressive and life-threatening human
malignancies, is known for its resistance to cytotoxic therapies. This is increasingly ascribed …
malignancies, is known for its resistance to cytotoxic therapies. This is increasingly ascribed …
Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and
outside the nucleus. However, it is currently unclear whether and how the distribution of …
outside the nucleus. However, it is currently unclear whether and how the distribution of …
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models
KB Teuscher, S Chowdhury… - Proceedings of the …, 2023 - National Acad Sciences
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein
complexes that perform a variety of critical chromatin-centric processes in the nucleus …
complexes that perform a variety of critical chromatin-centric processes in the nucleus …
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly
validated but challenging target for the development of anticancer therapies. Novel …
validated but challenging target for the development of anticancer therapies. Novel …
Impact of WIN site inhibitor on the WDR5 interactome
The chromatin-associated protein WDR5 is a promising pharmacological target in cancer,
with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called …
with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called …
Design, synthesis, and evaluation of WD-repeat-containing protein 5 (WDR5) degraders
A Dölle, B Adhikari, A Krämer… - Journal of medicinal …, 2021 - ACS Publications
Histone H3K4 methylation serves as a post-translational hallmark of actively transcribed
genes and is introduced by histone methyltransferase (HMT) and its regulatory scaffolding …
genes and is introduced by histone methyltransferase (HMT) and its regulatory scaffolding …
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
WL Cai, JFY Chen, H Chen, E Wingrove, SJ Kurley… - Elife, 2022 - elifesciences.org
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and
there are few effective therapies against this advanced disease. Emerging evidence …
there are few effective therapies against this advanced disease. Emerging evidence …
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies
WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC
oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene …
oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene …