A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero‐
oligomers continues to gain experimental support. However, with the exception of the …

Methionine adenosyltransferases (MATs) are the family of enzymes that synthesize the main
biological methyl donor, S-adenosylmethionine. The high sequence conservation among …

Protein–protein interactions can be designed computationally by using positive strategies
that maximize the stability of the desired structure and/or by negative strategies that seek to …

Covering: July 2010 to August 2019. Previous review: Nat. Prod. Rep., 2011, 28, 594 The
review covers recent progress on the isolation, identification, bioactivity and biomimetic …

The folding of multisubunit proteins is of tremendous biological significance since the large
majority of proteins exist as protein–protein complexes. Extensive experimental and …

G protein-coupled receptors (GPCRs) have been proven to be the largest family of
druggable targets in the human genome. Given the importance of GPCRs as drug targets …

Whether membrane-anchored PD-L1 homodimerizes in living cells is controversial. The
biological significance of the homodimer waits to be expeditiously explored. However …

Some thermophilic enzymes not only exhibit high thermostability at high temperatures but
also have an activation effect by thermal incubation. However, the correlations between …

The ability to inhibit host cell apoptosis is important for the intracellular replication of the
obligate intracellular pathogen Coxiella burnetii, as it allows the completion of the lengthy …