Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …

The application of stem cells in regenerative and reparative therapies is emerging in
surgery. Published information can lead to an over simplified view of stem cells with respect …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

Human embryonic stem cells (hESCs) have enormous potential as a source of cells for cell
replacement therapies and as a model for early human development. In this study we …

Human embryonic stem cells have been defined as self-renewing cells that can give rise to
many types of cells of the body. How and whether these cells can be manipulated to replace …

Stem cells are a relevant source of information about cellular differentiation, molecular
processes and tissue homeostasis, but also one of the most putative biological tools to treat …

The promise of human embryonic stem cell (hESC) lines for treating injuries and
degenerative diseases, for understanding early human development, for disease modelling …

The capacity of human embryonic stem cells (hESCs) to self-renew indefinitely in culture
while retaining their ability to differentiate into all cell types suggests that they have …

Cell replacement therapy is a promising approach for the treatment of cardiac diseases. It is,
however, challenged by a limited supply of appropriate cells. Therefore, we have …

Mechanical forces have been reported to induce proliferation and/or differentiation in many
cell types, but the role of mechanotransduction during embryonic stem cell fate decisions is …