[HTML][HTML] Myokines and resistance training: a narrative review

BEM Zunner, NB Wachsmuth, ML Eckstein… - International journal of …, 2022 - mdpi.com
In the last few years, the muscular system has gained attention due to the discovery of the
muscle-secretome and its high potency for retaining or regaining health. These cytokines …

A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: an introductory review

H Askari, SF Rajani, M Poorebrahim… - Pharmacological …, 2018 - Elsevier
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

JJ Slate-Romano, N Yano, TC Zhao - Molecular and cellular endocrinology, 2022 - Elsevier
Irisin is an exercise induced myokine first shown to induce the browning of white adipose
tissue (WAT) which increases energy expenditure, improves glucose tolerance, and reduces …

[HTML][HTML] Integrin-ligand interactions in inflammation, cancer, and metabolic disease: Insights into the multifaceted roles of an emerging ligand irisin

EJ Park, PK Myint, A Ito, MG Appiah… - Frontiers in cell and …, 2020 - frontiersin.org
Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …

[HTML][HTML] The role of irisin in Alzheimer's disease

OY Kim, J Song - Journal of clinical medicine, 2018 - mdpi.com
Alzheimer's disease (AD) is characterized by progressive memory dysfunction, oxidative
stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the …

[HTML][HTML] The role of irisin in cancer disease

A Pinkowska, M Podhorska-Okołów, P Dzięgiel… - Cells, 2021 - mdpi.com
Irisin (Ir) is an adipomyokine that is involved in the regulation of metabolic processes. It also
influences processes related to inflammation, including cancer. Initially, Ir was considered a …

Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma

G Shi, N Tang, J Qiu, D Zhang, F Huang… - Biochemical and …, 2017 - Elsevier
Irisin is a newly identified myokine that may be cancer-associated, and its impact on liver
cancer is unclear. To understand the roles of irisin in liver cancer, we investigated its effect in …

[HTML][HTML] Irisin at the crossroads of inter-organ communications: Challenge and implications

R Zhao - Frontiers in Endocrinology, 2022 - frontiersin.org
The physiological functions of organs are intercommunicated occurring through secreted
molecules. That exercise can improve the physiological function of organs or tissues is …

Exercise‐Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

GE Maalouf, D El Khoury - Journal of obesity, 2019 - Wiley Online Library
Irisin is a recently discovered myokine that plays an important role in fat metabolism through
the browning of white adipose tissue. This myokine is usually secreted after exercise by …

[HTML][HTML] FNDC5: A novel player in metabolism and metabolic syndrome

RY Cao, H Zheng, D Redfearn, J Yang - Biochimie, 2019 - Elsevier
Half a decade ago, transmembrane protein fibronectin type III domain-containing protein 5
(FNDC5) was found to be cleaved as a novel myokine irisin, which burst into prominence for …