Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic
centromeres have been shown to be an astonishing example of epigenetic change within …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how …

We have generated and characterized a novel site-specific antibody highly specific for the
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

Data are presented for sequence-specific chromatin-loop organization in histone-depleted
nuclei from Drosophila melanogaster Kc cells. We find one loop for each of the tandemly …

We have obtained a polyclonal antibody that recognizes a major polypeptide component of
chicken mitotic chromosome scaffolds. This polypeptide migrates in SDS PAGE with Mr …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

DNA topoisomerases participate in nearly all events relating to DNA metabolism including
replication, transcription, and chromosome segregation. Recent studies in eukaryotic cells …

This laboratory has previously isolated a fraction from rat liver nuclei consisting of nuclear
pore complexes associated with the proteinaceous lamina which underlies the inner nuclear …