An epidemiological introduction to human metabolomic investigations

AD Joshi, A Rahnavard, P Kachroo, KM Mendez… - Trends in Endocrinology …, 2023 - cell.com
Metabolomics holds great promise for uncovering insights around biological processes
impacting disease in human epidemiological studies. Metabolites can be measured across …

Amino acids metabolism in retinopathy: from clinical and basic research perspective

M Xia, F Zhang - Metabolites, 2022 - mdpi.com
Retinopathy, including age-related macular degeneration (AMD), diabetic retinopathy (DR),
and retinopathy of prematurity (ROP), are the leading cause of blindness among seniors …

Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners

AM Evans, C O'Donovan, M Playdon, C Beecher… - Metabolomics, 2020 - Springer
Introduction The metabolomics quality assurance and quality control consortium (mQACC)
evolved from the recognized need for a community-wide consensus on improving and …

[HTML][HTML] Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK consortium

IE Acar, L Lores-Motta, JM Colijn, MA Meester-Smoor… - Ophthalmology, 2020 - Elsevier
Purpose The current study aimed to identify metabolites associated with age-related
macular degeneration (AMD) by performing the largest metabolome association analysis in …

Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration

X Han, I Lains, J Li, J Li, Y Chen, B Yu, Q Qi… - Cell Reports …, 2023 - cell.com
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults.
Investigating shared genetic components between metabolites and AMD can enhance our …

Proline metabolism and transport in retinal health and disease

J Du, S Zhu, RR Lim, JR Chao - Amino acids, 2021 - Springer
The retina is one of the most energy-demanding tissues in the human body. Photoreceptors
in the outer retina rely on nutrient support from the neighboring retinal pigment epithelium …

A proteogenomic signature of age-related macular degeneration in blood

V Emilsson, EF Gudmundsson, T Jonmundsson… - Nature …, 2022 - nature.com
Age-related macular degeneration (AMD) is one of the most common causes of visual
impairment in the elderly, with a complex and still poorly understood etiology. Whole …

Metabolomics in age-related macular degeneration: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2020 - iovs.arvojournals.org
Purpose: Age-related macular degeneration (AMD) is one of the leading causes of
blindness among the elderly, and the exact pathogenesis of the AMD remains unclear. The …

Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells

H Zheng, M Li, T Zhou, Y Wang, EX Shang, Y Hua… - Food & Function, 2023 - pubs.rsc.org
In this study, we investigated the preventive effect of Lycium barbarum L. berry extract on
age-related macular degeneration (AMD) and the main components responsible for its …

[HTML][HTML] Artificial intelligence analysis of biofluid markers in age-related macular degeneration: a systematic review

A Pucchio, SH Krance, DR Pur… - Clinical …, 2022 - ncbi.nlm.nih.gov
This systematic review explores the use of artificial intelligence (AI) in the analysis of biofluid
markers in age-related macular degeneration (AMD). We detail the accuracy and validity of …