Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products

Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Squamous cell cancers: a unified perspective on biology and genetics

GP Dotto, AK Rustgi - Cancer cell, 2016 - cell.com
Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

[HTML][HTML] Clinicopathologic features of advanced squamous NSCLC

MA Socinski, C Obasaju, D Gandara, FR Hirsch… - Journal of Thoracic …, 2016 - Elsevier
Lung cancer remains the leading cause of cancer-related death worldwide. NSCLC
accounts for more than 85% of all lung cancers, and the prognosis for advanced-stage …

Targeting the fibroblast growth factor receptor (FGFR) family in lung cancer

L Pacini, AD Jenks, NC Lima, PH Huang - Cells, 2021 - mdpi.com
Lung cancer is the most common cause of cancer-related deaths globally. Genetic
alterations, such as amplifications, mutations and translocations in the fibroblast growth …

LUBAC determines chemotherapy resistance in squamous cell lung cancer

EJ Ruiz, ME Diefenbacher, JK Nelson… - Journal of Experimental …, 2019 - rupress.org
Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common
lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival …

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

EJ Ruiz, A Pinto-Fernandez, AP Turnbull, L Lan… - Elife, 2021 - elifesciences.org
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an
incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5 …

[HTML][HTML] TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin

W Xu, B Chen, D Ke, X Chen - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Lung squamous cell carcinoma (LSCC) is the most common histological type of primary lung
cancer. In this study, we had tested the biological role of TRIM29 in LSCC cells. TRIM29 …

Anticancer potential of Thevetia peruviana fruit methanolic extract

A Ramos-Silva, F Tavares-Carreón, M Figueroa… - … and alternative medicine, 2017 - Springer
Abstract Background Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.)
Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native …

[HTML][HTML] Incremental innovation and progress in advanced squamous cell lung cancer: current status and future impact of treatment

CJ Langer, C Obasaju, P Bunn, P Bonomi… - Journal of Thoracic …, 2016 - Elsevier
Squamous cell lung cancer (sqCLC) is an aggressive form of cancer that poses many
therapeutic challenges. Patients tend to be older, present at a later stage, and have a high …

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer

H Terai, L Tan, EM Beauchamp, JM Hatcher… - ACS chemical …, 2015 - ACS Publications
Despite advances in precision medicine approaches over the past decade, the majority of
nonsmall cell lung cancers (NSCLCs) are refractory to treatment with targeted small …