Activity-dependent modifications in synaptic efficacy, such as long-term depression (LTD)
and long-term potentiation (LTP), represent key cellular substrates for adaptive motor control …

In this review I outline the arguments as to whether we should consider Parkinson disease
one or more than one entity and discuss genetic findings from Mendelian and whole …

Missense mutations in the LRRK2 (Leucine-rich repeat protein kinase-2) and VPS35 genes
result in autosomal dominant Parkinson's disease. The VPS35 gene encodes for the cargo …

Lysosomal dysfunction plays a central role in the pathogenesis of several
neurodegenerative disorders, including Parkinson's disease (PD). Several genes linked to …

Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …

Mutations in leucine-rich repeat kinase 2 (LRRK2) have been causally linked to neuronal
cell death in Parkinson's disease. LRRK2 expression has also been detected in B …

It is now well established that chronic inflammation is a prominent feature of several
neurodegenerative disorders including Parkinson's disease (PD). Growing evidence …

Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease.
Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not …

Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic
Parkinson's disease (PD), yet its pathogenic role remains unclear. A previous screen in …

Recent reports attribute numerous regulatory functions to the nuclear paraspeckle-forming
long noncoding RNA, nuclear enriched assembly transcript 1 (NEAT1), but the implications …