Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …

BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

The AMP-activated protein kinase (AMPK) functions to monitor and maintain energy
homeostasis at the cellular and organism level. AMPK was perceived historically primarily …

The multifunctional AMPK-activated protein kinase (AMPK) is an evolutionarily conserved
energy sensor that plays an important role in cell proliferation, growth, and survival. It …

Background It is well established that tumors are dependent on angiogenesis for their
growth and survival. Although uterine fibroids are known to be benign tumors with reduced …

Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that
coordinately activate for mitochondrial generation. Here, we report that the Krebs cycle …

The proper functioning of the cell depends on preserving the cellular genome. In yeast cells,
a limited number of genes are located on mitochondrial DNA. Although the mechanisms …