The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

C Milani, S Duranti, F Bottacini, E Casey… - Microbiology and …, 2017 - Am Soc Microbiol
The human gut microbiota is engaged in multiple interactions affecting host health during
the host's entire life span. Microbes colonize the neonatal gut immediately following birth …

Type 1 diabetes—early life origins and changing epidemiology

JM Norris, RK Johnson, LC Stene - The lancet Diabetes & …, 2020 - thelancet.com
Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of
insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has …

[HTML][HTML] A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

ME Perez-Muñoz, MC Arrieta, AE Ramer-Tait, J Walter - microbiome, 2017 - Springer
After more than a century of active research, the notion that the human fetal environment is
sterile and that the neonate's microbiome is acquired during and after birth was an accepted …

Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults

EM Stoffel, CC Murphy - Gastroenterology, 2020 - Elsevier
In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …

[HTML][HTML] The association between early-life gut microbiota and long-term health and diseases

A Sarkar, JY Yoo, S Valeria Ozorio Dutra… - Journal of clinical …, 2021 - mdpi.com
Early life gut microbiota have been increasingly recognized as major contributors to short
and/or long-term human health and diseases. Numerous studies have demonstrated that …

Antibiotics, birth mode, and diet shape microbiome maturation during early life

NA Bokulich, J Chung, T Battaglia… - Science translational …, 2016 - science.org
Early childhood is a critical stage for the foundation and development of both the
microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding …

[HTML][HTML] The multifaceted roles of breast milk antibodies

C Atyeo, G Alter - Cell, 2021 - cell.com
Neonates are born with an immature immune system and rely on the transfer of immunity
from their mothers. Maternal antibodies are transferred via the placenta and breast milk …

The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

JF Bach - Nature Reviews Immunology, 2018 - nature.com
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …

[HTML][HTML] The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review

E Rutayisire, K Huang, Y Liu, F Tao - BMC gastroenterology, 2016 - Springer
Background The human gut is the habitat for diverse and dynamic microbial ecosystem. The
human microbiota plays a critical role in functions that sustain health and is a positive asset …

Food allergy

H Renz, KJ Allen, SH Sicherer, HA Sampson… - Nature reviews Disease …, 2018 - nature.com
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …