Synovial joint-on-a-chip for modeling arthritis: Progress, pitfalls, and potential

ZA Li, S Sant, SK Cho, SB Goodman, BA Bunnell… - Trends in …, 2023 - cell.com
Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

Vascularized adipose tissue engineering: moving towards soft tissue reconstruction

A Peirsman, HT Nguyen, M Van Waeyenberge… - …, 2023 - iopscience.iop.org
Soft tissue defects are a common clinical challenge mostly caused by trauma, congenital
anomalies and oncological surgery. Current soft tissue reconstruction options include …

Engineered marble-like bovine fat tissue for cultured meat

Y Zagury, I Ianovici, S Landau, N Lavon… - Communications …, 2022 - nature.com
Cultured meat can provide a sustainable and more ethical alternative to conventional meat.
Most of the research in this field has been focused on developing muscle tissue, as it is the …

Research progress, challenges, and breakthroughs of organoids as disease models

Y Huang, Z Huang, Z Tang, Y Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Traditional cell lines and xenograft models have been widely recognized and used in
research. As a new research model, organoids have made significant progress and …

Vascularized tissue organoids

HA Strobel, SM Moss, JB Hoying - Bioengineering, 2023 - mdpi.com
Tissue organoids hold enormous potential as tools for a variety of applications, including
disease modeling and drug screening. To effectively mimic the native tissue environment, it …

κ-Carrageenan/konjac glucomannan composite hydrogel-based 3D porcine cultured meat production

X Gu, S Hua, Y Huang, S Liu, Y Wang, M Zhou… - Food …, 2024 - Elsevier
Alternative technology for cultured meat production holds the potential to alleviate ethical,
environmental, and public health concerns stemming from conventional husbandry. As a key …

Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration

X Gao, S Ma, X Xing, J Yang, X Xu… - Journal of Tissue …, 2022 - journals.sagepub.com
The establishment of effective vascularization represents a key challenge in regenerative
medicine. Adequate sources of vascular cells and intact vessel fragments have not yet been …

Articular tissue-mimicking organoids derived from mesenchymal stem cells and induced pluripotent stem cells

ZA Li, J Shang, S Xiang, EN Li, H Yagi, K Riewruja… - Organoids, 2022 - mdpi.com
Organoids offer a promising strategy for articular tissue regeneration, joint disease
modeling, and development of precision medicine. In this study, two types of human stem …

Recent advancements and future requirements in vascularization of cortical organoids

E LaMontagne, AR Muotri, AJ Engler - Frontiers in Bioengineering …, 2022 - frontiersin.org
The fields of tissue engineering and disease modeling have become increasingly cognizant
of the need to create complex and mature structures in vitro to adequately mimic the in vivo …

Strategies in Electrospun Polymer and Hybrid Scaffolds for Enhanced Cell Integration and Vascularization for Bone Tissue Engineering and Organoids

M Polak, JE Karbowniczek… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Addressing the demand for bone substitutes, tissue engineering responds to the high
prevalence of orthopedic surgeries worldwide and the limitations of conventional tissue …