Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
JB Houston - Biochemical pharmacology, 1994 - Elsevier
In recent years, there has been a large expansion in both the range and use of in vitro
systems to study drug metabolism and metabolism-related phenomena. Purified enzymes …
systems to study drug metabolism and metabolism-related phenomena. Purified enzymes …
Predicting in vivo drug interactions from in vitro drug discovery data
LC Wienkers, TG Heath - Nature reviews Drug discovery, 2005 - nature.com
In vitro screening for drugs that inhibit cytochrome P450 enzymes is well established as a
means for predicting potential metabolism-mediated drug interactions in vivo. Given that …
means for predicting potential metabolism-mediated drug interactions in vivo. Given that …
Physiologically-based pharmacokinetics in drug development and regulatory science
M Rowland, C Peck, G Tucker - Annual review of pharmacology …, 2011 - annualreviews.org
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …
age in drug development and regulation, reflecting significant advances over the past 10 …
[图书][B] The toxicology of fishes
RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and …
ZE Barter, MK Bayliss, PH Beaune… - Current drug …, 2007 - ingentaconnect.com
Reported predictions of human in vivo hepatic clearance from in vitro data have used a
variety of values for the scaling factors human microsomal protein (MPPGL) and …
variety of values for the scaling factors human microsomal protein (MPPGL) and …
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
T Iwatsubo, N Hirota, T Ooie, H Suzuki… - Pharmacology & …, 1997 - Elsevier
As a new approach to predicting in vivo drug metabolism in humans, scaling of in vivo
metabolic clearance from in vitro data obtained using human liver microsomes or …
metabolic clearance from in vitro data obtained using human liver microsomes or …
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
MJ Mulvihill, A Cooke… - Future medicinal …, 2009 - Taylor & Francis
Background: The IGF-1 receptor (IGF-1R) has been implicated in the promotion of
tumorigenesis, metastasis and resistance to cancer therapies. Therefore, this receptor has …
tumorigenesis, metastasis and resistance to cancer therapies. Therefore, this receptor has …
Man versus beast: pharmacokinetic scaling in mammals
J Mordenti - Journal of pharmaceutical sciences, 1986 - Elsevier
Land mammals range in size from the 3-g shrew to the 3000-kg elephant. Despite this 10 6
range in weight, most land mammals have similar anatomy, physiology, biochemistry, and …
range in weight, most land mammals have similar anatomy, physiology, biochemistry, and …
[引用][C] Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and …
RS Obach - Drug Metabolism and Disposition, 1999 - ASPET
[引用][C] The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data
RS Obach, JG Baxter, TE Liston, BM Silber… - … of Pharmacology and …, 1997 - ASPET