SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We
show that components of the inflammasome are protective during acute and recurring colitis …

Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …

Macrophages are cells that function as a first line of defence against invading
microorganisms. One of the hallmarks of macrophages is their ability to become activated in …

The NOD-like receptors have important roles in innate immunity as intracellular sensors of
microbial components and cell injury. It has been proposed that these cytosolic proteins …

Candida albicans is an opportunistic fungal pathogen causing life-threatening mucosal and
systemic infections in immunocompromised humans. Using a murine model of mucosal …

Increasing evidence indicates that chronic inflammatory and immune responses play key
roles in the development and progression of COPD. Recent data provide evidence for a role …