All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …

Aging is a continuous process that induces many alterations in the cytoarchitecture of
different organs and systems both in humans and animals. Moreover, it is associated with …

Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is
highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies …

The thymus is the primary organ for T‐cell differentiation and maturation. Unlike other major
organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost …

The substantial importance of P‐selectin glycoprotein ligand 1 (PSGL‐1) in leukocyte
trafficking has continued to emerge beyond its initial identification as a selectin ligand. PSGL …

Similar to all haematopoietic lineages, T cells must be replenished throughout life—a
process that is the main function of the thymus. New progenitors are recruited to leave the …

Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell
development. We have previously reported that two subpopulations of common lymphoid …

Age-related thymic involution, leading to reduced T cell production, is one of the major
causes of immunosenescence. This results in an increased susceptibility to cancers …

T‐cell development in the thymus requires periodic importation of hematopoietic progenitors
from the bone marrow. Such thymus settling progenitors arise from hematopoietic stem cells …

The stromal microenvironment in the thymus is essential for generating a functional T cell
repertoire. Thymic epithelial cells (TECs) are numerically and phenotypically one of the most …