Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine protease
synthesized primarily by the liver. It mainly promotes the degradation of low-density …

PCSK9 degrades low-density lipoprotein cholesterol (LDL) receptors and subsequently
increases serum LDL cholesterol. Clinical trials show that inhibition of PCSK9 efficiently …

The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an
increased incidence and prevalence over the last years with a simultaneous decrease in its …

Lowering blood cholesterol levels efficiently reduces the risk of developing atherosclerotic
cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the …

Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

Heart failure (HF) is a complex clinical syndrome caused by various cardiovascular
diseases. Its main pathogenesis includes cardiomyocyte loss, myocardial energy …