Cholangiocarcinoma 2020: the next horizon in mechanisms and management

JM Banales, JJG Marin, A Lamarca… - Nature reviews …, 2020 - nature.com
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

[PDF][PDF] Intrahepatic cholangiocarcinoma: continuing challenges and translational advances

AE Sirica, GJ Gores, JD Groopman, FM Selaru… - …, 2019 - Wiley Online Library
Intrahepatic cholangiocarcinoma (iCCA) has over the last 10‐20 years become the focus of
increasing concern, largely due to its rising incidence and high mortality rates worldwide …

Comparison of clinical features and outcomes between intrahepatic cholangiocarcinoma and hepatocellular carcinoma in the United States

YT Lee, JJ Wang, M Luu, M Noureddin, NN Nissen… - …, 2021 - Wiley Online Library
Background and Aims Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular
carcinoma (HCC) are the most common primary liver cancers (PLCs). Differences in their …

Epidemiology of cholangiocarcinoma; United States incidence and mortality trends

MM Gad, AM Saad, M Faisaluddin, MA Gaman… - Clinics and research in …, 2020 - Elsevier
Background Cholangiocarcinoma is an aggressive malignancy with few available studies
assessing incidence and mortality. In this study, we aim to investigate trends of incidence …

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

K Mima, T Hamada, K Inamura, H Baba, T Ugai… - Gut …, 2023 - Taylor & Francis
Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy …

X Liu, J Yao, L Song, S Zhang, T Huang, Y Li - Journal for immunotherapy …, 2019 - Springer
Background Late-stage or recurrent intrahepatic cholangiocarcinoma (ICC) patients exhibit
poor prognosis due to limited sensitivity to chemotherapy or radiotherapy and coexistence of …

[HTML][HTML] Burden of mortality from hepatocellular carcinoma and biliary tract cancers by race and ethnicity and sex in US, 2018–2023

D Kim, R Manikat, K Wijarnpreecha… - Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Background/Aims The trends in mortality of hepatocellular carcinoma (HCC) and biliary tract
cancers stratified by sex and race/ethnicity in the US continue to evolve. We estimated the …

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based …

L An, R Zheng, S Zhang, R Chen… - Hepatobiliary …, 2021 - pmc.ncbi.nlm.nih.gov
Background Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)
are the most common subtypes of primary liver cancer, but nationwide incidence of both liver …

Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study

MJ Kang, J Lim, SS Han, HM Park, SW Kim, WJ Lee… - Scientific Reports, 2022 - nature.com
Biliary tract cancer (BTC) has been inconsistently identified according to its location in
epidemiological and clinical studies. This study retrospectively reviewed the treatment …

[HTML][HTML] Repurposing metformin for the treatment of gastrointestinal cancer

ADC Júnior, AC Bragagnoli, FO Costa… - World journal of …, 2021 - ncbi.nlm.nih.gov
Diabetes mellitus type 2 and cancer share many risk factors. The pleiotropic insulin-
dependent and insulin-independent effects of metformin might inhibit pathways that are …