Therapeutic cancer vaccines

M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies

J Gao, HA Pickett - Nature Reviews Cancer, 2022 - nature.com
Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

[HTML][HTML] Challenges and opportunities for pancreatic cancer immunotherapy

AS Bear, RH Vonderheide, MH O'Hara - Cancer cell, 2020 - cell.com
Pancreatic ductal adenocarcinoma (PDA) is among the most immune-resistant tumor types.
Its unique genomic landscape shaped by oncogenic drivers promotes immune suppression …

Pancreatic cancer: a review of risk factors, diagnosis, and treatment

ZY Zhao, W Liu - Technology in cancer research & treatment, 2020 - journals.sagepub.com
This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

Immunotherapy for pancreatic cancer: A 2020 update

D Schizas, N Charalampakis, C Kole… - Cancer treatment …, 2020 - Elsevier
Pancreatic adenocarcinoma (PAC) is associated with extremely poor prognosis and remains
a lethal malignancy. The main cure for PAC is surgical resection. Further treatment …

A review on nano-based drug delivery system for cancer chemoimmunotherapy

W Mu, Q Chu, Y Liu, N Zhang - Nano-Micro Letters, 2020 - Springer
Although notable progress has been made on novel cancer treatments, the overall survival
rate and therapeutic effects are still unsatisfactory for cancer patients …

Therapeutic developments in pancreatic cancer: current and future perspectives

JP Neoptolemos, J Kleeff, P Michl, E Costello… - Nature reviews …, 2018 - nature.com
The overall 5-year survival for pancreatic cancer has changed little over the past few
decades, and pancreatic cancer is predicted to be the second leading cause of cancer …

Pancreatic ductal adenocarcinoma: current and evolving therapies

A Adamska, A Domenichini, M Falasca - International journal of molecular …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

Broadening the impact of immunotherapy to pancreatic cancer: challenges and opportunities

VP Balachandran, GL Beatty, SK Dougan - Gastroenterology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …