VEGF signaling: Role in angiogenesis and beyond
P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …
Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer …
Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
Cancer stem cells and the tumor microenvironment in tumor drug resistance
Q Gao, Y Zhan, L Sun, W Zhu - Stem Cell Reviews and Reports, 2023 - Springer
Although there has been some progress in the efficacy of anti-cancer drugs, drug resistance
remains challenging. Cancer stem cells (CSCs) are self-renewing and differentiate into …
remains challenging. Cancer stem cells (CSCs) are self-renewing and differentiate into …
Hypoxia inducible factor-1α (HIF-1α) in breast cancer: The crosstalk with oncogenic and onco-suppressor factors in regulation of cancer hallmarks
Low oxygen level at tumor microenvironment leads to a condition, known as hypoxia that is
implicated in cancer progression. Upon hypoxia, HIF-1α undergoes activation and due to its …
implicated in cancer progression. Upon hypoxia, HIF-1α undergoes activation and due to its …
Nano formulated Resveratrol inhibits PD-L1 in oral cancer cells by deregulating the association between tumor associated macrophages and cancer associated …
Tumor associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the
tumor microenvironment secrete several cytokines, which involved in tumor initiation …
tumor microenvironment secrete several cytokines, which involved in tumor initiation …
Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies
K Ali, M Nabeel, F Mohsin, M Iqtedar, M Islam… - Medical Oncology, 2024 - Springer
Despite recent advancements in the diagnosis and treatment of breast cancer (BC), patient
outcomes in terms of survival, recurrence, and disease progression remain suboptimal. A …
outcomes in terms of survival, recurrence, and disease progression remain suboptimal. A …
α-Amylase and mycobacterium-TB H37Rv antagonistic efficacy of novel pyrazole-coumarin hybrids: an in vitro and in silico investigation
DC Kanjariya, HN Naik, MJ Sherashiya… - Journal of …, 2024 - Taylor & Francis
The present investigation of minutiae to acquire structural information of the novel pyrazole-
coumarin hybrids (PC1-PC10) synthesized using ultrasound methods and characterized …
coumarin hybrids (PC1-PC10) synthesized using ultrasound methods and characterized …
Synergistic Therapy of Metastatic Breast Cancers by Biomimetic Chemotherapeutic Drug-Gene Nanoparticles
J Ren, Y Han, J Xu, T Chen, W Huang… - ACS Applied Materials & …, 2024 - ACS Publications
Cancer metastasis is responsible for more than 90% of tumor-related deaths. Especially,
metastatic breast cancer (MBC) is a common malignancy with a high mortality among …
metastatic breast cancer (MBC) is a common malignancy with a high mortality among …
c-Met pathway in human malignancies and its targeting by natural compounds for cancer therapy
CD Mohan, MK Shanmugam, SGS Gowda… - Phytomedicine, 2024 - Elsevier
Background c-MET is a receptor tyrosine kinase which is classically activated by HGF to
activate its downstream signaling cascades such as MAPK, PI3K/Akt/mTOR, and STAT3 …
activate its downstream signaling cascades such as MAPK, PI3K/Akt/mTOR, and STAT3 …
AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data
Cancer stem cells (CSCs) are a subpopulation of cancer cells within tumors that exhibit stem-
like properties and represent a potentially effective therapeutic target toward long-term …
like properties and represent a potentially effective therapeutic target toward long-term …