Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs
and link them to cellular membranes. They integrate cellular architectural and signalling …

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium
not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a …

Background: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment
to the plasmatic membrane. FLNC mutations have been associated with myofibrillar …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous
actin in networks and stress fibers. Over the past few years it has become clear that filamins …

Like the ancient Greek hero Hercules, striated muscle is famous for performing impressive
feats of strength. The procurement of food, breathing, and defense or escape from harm all …

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant
proteins result in perturbations of many cellular components. MDs have been associated …

Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding
proteins that organize the actin cytoskeleton and maintain extracellular matrix connections …

Myofibrillar myopathies (MFMs) represent a group of muscular dystrophies with a similar
morphological phenotype. The diagnosis is established by muscle biopsy. The MFMs are …