Recent updates on drug resistance in Mycobacterium tuberculosis
R Singh, SP Dwivedi, US Gaharwar… - Journal of applied …, 2020 - academic.oup.com
Tuberculosis (TB) along with acquired immune deficiency syndrome and malaria rank
among the top three fatal infectious diseases which pose threat to global public health …
among the top three fatal infectious diseases which pose threat to global public health …
Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis
Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …
Treatment of drug-resistant tuberculosis. An official ATS/CDC/ERS/IDSA clinical practice guideline
Background: The American Thoracic Society, US Centers for Disease Control and
Prevention, European Respiratory Society, and Infectious Diseases Society of America …
Prevention, European Respiratory Society, and Infectious Diseases Society of America …
The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis
The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains
HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …
worldwide today. Escalating application of genomic techniques has expedited the …
The isoniazid paradigm of killing, resistance, and persistence in Mycobacterium tuberculosis
C Vilchèze, WR Jacobs Jr - Journal of molecular biology, 2019 - Elsevier
Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …
Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis
For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …
Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis
RR Nathavitharana, PGT Cudahy… - European …, 2017 - Eur Respiratory Soc
Only 25% of multidrug-resistant tuberculosis (MDR-TB) cases are currently diagnosed. Line
probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and …
probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and …
[HTML][HTML] Bacterial factors that predict relapse after tuberculosis therapy
R Colangeli, H Jedrey, S Kim, R Connell… - … England Journal of …, 2018 - Mass Medical Soc
Background Approximately 5% of patients with drug-susceptible tuberculosis have a relapse
after 6 months of first-line therapy, as do approximately 20% of patients after 4 months of …
after 6 months of first-line therapy, as do approximately 20% of patients after 4 months of …
Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations
The majority of Mycobacterium tuberculosis isolates resistant to isoniazid harbour a mutation
in katG. Since these mutations cause a wide range of minimum inhibitory concentrations …
in katG. Since these mutations cause a wide range of minimum inhibitory concentrations …