Natural killer (NK) cells can defend an organism against a variety of threats, probably using
several different strategies to discriminate between normal and~ berrant cells. According to …

▪ Abstract Natural killer cells are likely to play an important role in the host defenses because
they kill virally infected or tumor cells but spare normal self-cells. The molecular mechanism …

IRRADIATED MHC-heterozygous mice often reject bone marrow cells transplanted from one
of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to …

From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …

The idea that NK cells can distinguish aberrant cells by recognizing'absence of the
expected', rather than'presence of the unexpected'emerged more than 25 years ago. Klas …

The development of malignant disease might be seen as a failure of immune surveillance.
However, not all tumors are naturally immunogenic, and even among those that are …

This article is based on a lecture presented at the Novartis Prize ceremony at the
International Congress of Immunology in July 2001. It gives a personal and historical …

Heterogeneity in the natural killer (NK) cell population is determined by variegated
expression of polygenic and polymorphic receptors and distinct phenotypes and functions of …

Abstract SELF-REACTIVE B cells can be regulated by either deletion or inactivation1. These
manifestations of self-tolerance have been dramatically shown in transgenic mice in which …

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex
(MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers “missing …