Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …

Understanding the changes in the brain which occur in the transition from normal to
addictive behavior has major implications in public health. Here we postulate that while …

The prefrontal cortex in rats can be distinguished anatomically from other frontal cortical
areas both in terms of cytoarchitectonic characteristics and neural connectivity, and it can be …

Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated.
The transient inhibition of brain nuclei associated with motor systems [including the ventral …

Repeated exposure to psychostimulants such as cocaine and amphetamine produces
behavioral sensitization, which is characterized by an augmented locomotor response to a …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

A compelling model of experience-dependent plasticity is the long-lasting sensitization to
the locomotor stimulatory effects of drugs of abuse. Adaptations in the nucleus accumbens …

The reinforcing (rewarding) effects of psychomotor stimulants (cocaine and amphetamine)
depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens …

Elevated dopamine transmission in the nucleus accumbens is thought to be a primary
mediator of addiction to cocaine. However, repeated exposure to cocaine is associated with …