A method of enhancing the permeability of the skin to an analyte for diagnostic purposes or
to a drug for therapeutic purposes is described utilizing microporation and optionally Sonic …

A method of enhancing the permeability of the skin to an analyte for diagnostic purposes or
to a drug for therapeutic purposes is described utilizing microporation and optionally sonic …

[57] ABSTRACT An apparatus (120) useful for. among other things. subcu taneous drug
delivery includes a housing (124). a? uid reservoir (154) disposed within the housing for …

(57) ABSTRACT A method of enhancing the permeability of a biological membrane,
including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is …

Related US Application Data Continuation of application No. 10/284.408, filed on Oct. 31,
2002, now abandoned, which is a continuation of application No. 09/331,124, filed as …

US20040039342A1 - Transdermal integrated actuator device, methods of making and
using same - Google Patents US20040039342A1 - Transdermal integrated actuator device …

5,421,816 5,423,803 5.425, 728 5,427,585 5,445,611 5,458,140 5,459,127 5,462.520
5,547.467 5,548,140 5,554,153 5,580,859 5,582,586 5,611,806 5,651,768 5,713,845 …

An improved method and apparatus is provided as a System to deliver a composition,
preferably a medical or pharma ceutical composition or active, through the Stratum corneum …

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with
cavities corresponding to the negative of the microprotrusions, casting atop the mold a first …

A microneedle applicator is provided which has two roughly concentric portions which may
be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the …