Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Machine learning for metabolic engineering: A review

CE Lawson, JM Martí, T Radivojevic… - Metabolic …, 2021 - Elsevier
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …

Review on machine learning-based bioprocess optimization, monitoring, and control systems

PP Mondal, A Galodha, VK Verma, V Singh… - Bioresource …, 2023 - Elsevier
Abstract Machine Learning is quickly becoming an impending game changer for
transforming big data thrust from the bioprocessing industry into actionable output. However …

Protein sequence design with deep generative models

Z Wu, KE Johnston, FH Arnold, KK Yang - Current opinion in chemical …, 2021 - Elsevier
Protein engineering seeks to identify protein sequences with optimized properties. When
guided by machine learning, protein sequence generation methods can draw on prior …

Artificial intelligence and machine learning approaches for drug design: challenges and opportunities for the pharmaceutical industries

C Selvaraj, I Chandra, SK Singh - Molecular diversity, 2021 - Springer
The global spread of COVID-19 has raised the importance of pharmaceutical drug
development as intractable and hot research. Developing new drug molecules to overcome …

Machine learning in bioprocess development: from promise to practice

LM Helleckes, J Hemmerich, W Wiechert… - Trends in …, 2023 - cell.com
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics

X Tan, JH Letendre, JJ Collins, WW Wong - Cell, 2021 - cell.com
Synthetic biology is a design-driven discipline centered on engineering novel biological
functions through the discovery, characterization, and repurposing of molecular parts …

Recent advances in machine learning applications in metabolic engineering

P Patra, BR Disha, P Kundu, M Das, A Ghosh - Biotechnology Advances, 2023 - Elsevier
Metabolic engineering encompasses several widely-used strategies, which currently hold a
high seat in the field of biotechnology when its potential is manifesting through a plethora of …

A versatile active learning workflow for optimization of genetic and metabolic networks

A Pandi, C Diehl, A Yazdizadeh Kharrazi… - Nature …, 2022 - nature.com
Optimization of biological networks is often limited by wet lab labor and cost, and the lack of
convenient computational tools. Here, we describe METIS, a versatile active machine …