The immunology of Epstein-Barr virus–induced disease
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
Central memory and effector memory T cell subsets: function, generation, and maintenance
The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
ME Dudley, JR Wunderlich, PF Robbins, JC Yang… - Science, 2002 - science.org
We report here the adoptive transfer, to patients with metastatic melanoma, of highly
selected tumor-reactive T cells directed against overexpressed self-derived differentiation …
selected tumor-reactive T cells directed against overexpressed self-derived differentiation …
Epstein–Barr virus: 40 years on
LS Young, AB Rickinson - Nature Reviews Cancer, 2004 - nature.com
Epstein–Barr virus (EBV) was discovered 40 years ago from examining electron
micrographs of cells cultured from Burkitt's lymphoma, a childhood tumour that is common in …
micrographs of cells cultured from Burkitt's lymphoma, a childhood tumour that is common in …
Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice
V Dasari, LK McNeil, K Beckett, M Solomon… - Nature …, 2023 - nature.com
The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …
sclerosis has generated considerable interest in the development of an effective vaccine …
[HTML][HTML] Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
B Keymeulen, E Vandemeulebroucke… - New England journal …, 2005 - Mass Medical Soc
Background Type 1 diabetes mellitus is a T-cell–mediated autoimmune disease that leads to
a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …
a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …
Cellular responses to viral infection in humans: lessons from Epstein-Barr virus
AD Hislop, GS Taylor, D Sauce… - Annu. Rev. Immunol …, 2007 - annualreviews.org
Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …
Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
Four human CD8+ T-cell subsets, naive (CCR7+ CD45RA+), central memory (TCM, CCR7+
CD45RA–), effector memory (TEM, CCR7–CD45RA–), and CD45RA+ effector memory cells …
CD45RA–), effector memory (TEM, CCR7–CD45RA–), and CD45RA+ effector memory cells …
Memory inflation: continuous accumulation of antiviral CD8+ T cells over time
U Karrer, S Sierro, M Wagner, A Oxenius… - The Journal of …, 2003 - journals.aai.org
CD8+ T lymphocytes play an important role in the control of intracellular pathogens during
both acute and persistent infections. This is particularly true in the case of persistent …
both acute and persistent infections. This is particularly true in the case of persistent …